Metabolic and hormonal changes during and after exchange transfusion with heparinized or ACD blood

摘要

Plasma glucose, free fatty acid (FFA), insulin, and growth hormone concentrations were measured during and for 3 hours after exchange transfusion in two comparable groups of newborn infants suffering from jaundice due to haemolytic disease, infection, or prematurity. 10 transfusions were performed using blood preserved with acid citrate and dextrose (ACD) and in these there was a doubling of plasma glucose and a fourfold rise in plasma insulin. Plasma FFA fell in ACD transfusions but doubled during 9 transfusions in which heparinized blood was used. Plasma glucose and insulin remained unchanged in heparin transfusions and no significant change in plasma growth hormone occurred during or after either type of transfusion.